Перевод и анализ слов искусственным интеллектом ChatGPT
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Что (кто) такое repair items - определение
![DNA ligase, shown above repairing chromosomal damage, is an enzyme that joins broken nucleotides together by catalyzing the formation of an internucleotide [[ester]] bond between the phosphate backbone and the deoxyribose nucleotides.](https://commons.wikimedia.org/wiki/Special:FilePath/DNA Repair.jpg?width=200 "DNA ligase, shown above repairing chromosomal damage, is an enzyme that joins broken nucleotides together by catalyzing the formation of an internucleotide [[ester]] bond between the phosphate backbone and the deoxyribose nucleotides.")
![Structure of the base-excision repair enzyme [[uracil-DNA glycosylase]] excising a hydrolytically-produced uracil residue from DNA. The uracil residue is shown in yellow.](https://commons.wikimedia.org/wiki/Special:FilePath/Uracil base glycosidase.jpg?width=200 "Structure of the base-excision repair enzyme [[uracil-DNA glycosylase]] excising a hydrolytically-produced uracil residue from DNA. The uracil residue is shown in yellow.")
![6}} was the first [[United States Navy]] ship built as a repair ship.](https://commons.wikimedia.org/wiki/Special:FilePath/USS Medusa (AR-1) at Pearl Harbor February 1942.jpg?width=200 "6}} was the first [[United States Navy]] ship built as a repair ship.")
Википедия
Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by specific glycosylases. Similarly, the MMR pathway only targets mismatched Watson-Crick base pairs.
Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts - these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains the lesion. The undamaged single-stranded DNA remains and DNA polymerase uses it as a template to synthesize a short complementary sequence. Final ligation to complete NER and form a double stranded DNA is carried out by DNA ligase. NER can be divided into two subpathways: global genomic NER (GG-NER or GGR) and transcription coupled NER (TC-NER or TCR). The two subpathways differ in how they recognize DNA damage but they share the same process for lesion incision, repair, and ligation.
The importance of NER is evidenced by the severe human diseases that result from in-born genetic mutations of NER proteins. Xeroderma pigmentosum and Cockayne's syndrome are two examples of NER associated diseases.
